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Specialist supplements such as DHEA, high-dose myo-inositol, or NAC may be appropriate, but should be discussed with a clinician particularly DHEA, which is only indicated for diminished ovarian reserve

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Consistent with this, whole-exome sequencing of an osteosarcoma patient cohort identified a P-domain mutation involving a non-frameshift substitution of Tyr150 with Lys-Pro (T150PK) 62

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