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PubMed Central , Neuropsychopharmacology Reports , vol

Musillo C, Creutzberg KC, Collacchi B, Ajmone-Cat MA, De Simone R, Lepre M, et al

Wu Z, Huang S, Li T, Li N, Han D, Zhang B, et al

In metabolic dysfunctionassociated steatohepatitis (MASH), for example, it remains uncertain whether improvements in hepatic inflammation and fibrosis are exclusively secondary to weight loss and metabolic improvements, or whether direct hepatoprotective mechanisms are involved

To put this into perspective, health news outlet STAT recently estimated that 2025 spending on semaglutide and tirzepatide was 11% of total retail drug spending, a mind-boggling stat for just two drugs

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