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10.1016/j.exger.2017.02.004 32 HuangS.LiuH.LinY.LiuM.LiY.MaoH.et al (2020)

[1] However, because B12 is water-soluble, the body typically eliminates excess amounts through renal excretion without adverse effects

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Because the loss of these neurotrophic factors has been implicated in the pathogenesis of various neurodegenerative diseases, our results provide a potentially important mechanism whereby Hex may ameliorate or delay neurodegeneration in AD