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Bruising at the injection site affects up to 30% of patients starting semaglutide therapy, though most cases resolve within days
It is approved specifically for chronic weight loss and for moderate to severe obstructive sleep apnea in adults with obesity
High temperatures during shipping or prolonged storage above recommended conditions can cause irreversible aggregation
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Saxenda was also noted to cause hypoglycemia (low blood sugar) when used with some other anti-diabetic drugs (sulfonylureas)
Some studies and clinical experience suggest that older people on GLP-1s need careful attention to muscle mass and protein intake to avoid functional decline
The gradual titration protocol exists specifically to manage this
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