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In trials by the New England Journal of Medicine, it was found that participants with overweight or obesity, once weekly semaglutide, plus lifestyle intervention (this is key!) was associated with sustained, clinically relevant reduction in body weight

This drives the need for a gradual dose increase, as described below

CBT-I (Cognitive Behavioral Therapy for Insomnia) Mechanism: Behavioral/psychological intervention with the strongest long-term evidence for chronic insomnia

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Injectable semaglutide (Ozempic, Wegovy) is administered weekly via subcutaneous injection

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