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Type 2 Diabetes Mellitus [ DM2 ] DM2 can be associated with a gain-of-function mutation, resulting in increased expression of the a 2A -adrenergic receptor
Phosphonate-based irreversible inhibitors of human -glutamyl transpeptidase (GGT)
N.ChowA
Doi:10.1038/nature03000 Malinda KM, Sidhu GS, Mani H, et al
Maintenance Therapy: Once the big dose is done, smaller doses are given every 1-3 months
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