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L-carnitine is absorbed most quickly when taken on an empty stomach or with a simple carbohydrate
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These include dietary modifications (avoiding foods that trigger reflux), lifestyle changes (such as weight loss, elevating the head of the bed, and not eating late at night), and possibly using medications to reduce stomach acid
Eating regular, balanced meals rather than grazing throughout the day allows for more robust GLP-1 pulses
Many people prefer Friday or Saturday evenings so they can rest over the weekend if side effects occur
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