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NAFLD-associated chronic low-grade inflammation responds to L-carnitine supplementation through reduced hepatic pro-inflammatory cytokines (e.g., IL-6), increased anti-inflammatory cytokine IL-10, and downregulation of key inflammatory pathway components (TLR4, NF-B, JNK) (28)
Meaningful change in bloating, food tolerance, and digestive comfort is usually noticeable by 30 days
It may increase IGF-1, so monitoring is essential
2025 Jan;103(1):113-126
Acromegaly is treated by reducing GH levels or GH actions to the level by which IGF-1 normalizes, and T1DM is treated by insulin until HbA1c levels normalize [1-4]
Authors contributions RS conceived and designed the experiments
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