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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
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Researchers are now starting to investigate whether similar benefits could be seen with semaglutide
Currently available GLP-1 options like semaglutide and tirzepatide have demonstrated safety in seniors, with the STEP and SURMOUNT trials including participants up to age 75
In addition, VEGF/VEGFR2 signaling plays a critical role in tumor angiogenesis (Shah et al., 2020)
Wegovy should be injected once weekly on the same day
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