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This dual-pathway approach produces body composition changes that are faster and more complete than either peptide achieves independently

This is critical, since accelerated matrix degradation underlies disease progression

The third arm is what sets retatrutide apart from every approved incretin drug: glucagon-receptor agonism

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Investigators also collected serial blood samples to track shifts in lipids, C-reactive protein, and liver enzymes, providing a broader picture of metabolic health

It modulates brain circuits involved in libido rather than directly altering gonadotropins