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In the SUMMIT HFpEF trial, a 38% lower risk of cardiovascular death or worsening heart failure was reported, alongside changes in cardiometabolic and lipid markers
Birkenfeld emphasizes that a decrease in muscle mass in the context of successful weight loss is usually a physiological adaptation: "Greater weight loss is usually accompanied by an adjustment in muscle mass [...]
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The outcomes were (1) at-risk steatohepatitis defined as Fibroscan-AST (FAST) score 0.67, (2) significant or advanced fibrosis defined by liver stiffness measurement (LSM) 8.8 and 11.7 respectively, and (3) advanced fibrosis defined by AGILE3+ score 0.68
While this a frustrating side effect, you can take comfort in knowing that youre not alone
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