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Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: ASCO guideline update
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some supportive measures used to prevent or reduce it are adjustment of drugs with possible interactions, hyperhydration, alkalinization to favor the elimination of methotrexate metabolites (7-OH-methotrexate and 4-deoxy-4-amino-N-10-methylpteroic acid), and leucovorin salvage and even new alternatives have been sought, such as the use of silymarin [104, 105]
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The injection means they dont have to remember to take a supplement pill each day
doi: 10.1001/archneurol.2010.227 116 DreherSIGrubbaPvon ToerneCMoruzziAMaurerJGojTet al
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