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PAR2 was detected in chondrocytes and synovial tissues from OA patients, while expression of PAR2 in OA chondrocytes was upregulated by IL-1/TNF (108, 109)
Recent studies indicate its important role in stem cell biology and anti-tumor defense
Potential side effects to be aware of include: Bruising or tenderness where the IV catheter is placed
This phase of the reaction is a key step in melanin synthesis
The bulk of data sits in rodent models, with the brain-gut axis as the theoretical framework that connects the peripheral and central effects
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