It is worth mentioning that several LVs share the same pathways, e.g., keratinization can be found for LVs 2, 7, 62, and 80, corroborating the involvement of this pathway in the bioactivity induced by the materials (Supplementary Figure S4)
The modest rating volume means it should be treated as early marketplace feedback rather than strong validation
Sci Total Environ 548549(April):463471
The PPP in erythrocytes is the only pathway for these cells to produce NADPH, therefore, any defect in the production of NADPH, such as due to deficiencies in glucose-6-phosphate dehydrogenase, will have profound effects on erythrocyte survival
Furthermore, the combination of resveratrols Nrf2-activating antioxidant effects in normal cells with its pro-oxidant activity in copper-rich malignancies provides a biochemical basis for selective cytotoxicity [127]
It is a signal to slow down and evaluate the delivery method, not necessarily a sign of toxicity