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For the treatment policy estimand, the observed reductions in HbA 1c and body weight were dose dependent, a finding that is consistent with the results using the treatment policy estimand in the global PIONEER programme [12,13,14,15,16,17,18,19]
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Understanding this dual mechanism matters clinically
However, the frequencies of these autoreactive T-cell populations in the peripheral blood of T1D patients is comparable to those observed in healthy individuals
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