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The same April 2026 Nature study identified two specific genetic variants with meaningful implications

Athauda D, Maclagan K, Skene SS, Bajwa-Joseph M, Letchford D, Chowdhury K, et al

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IDH1 mutations cause significant changes in enzymatic reactions, catalyzing the large-scale conversion of -ketoglutarate (2-KG) to 2-hydroxyglutarate (2-HG), and cause significant changes in the cells metabolic system

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