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others require higher maintenance doses or longer treatment duration to overcome plateau
They need a few practical guardrails consistent hydration, a protein anchor, smaller-but-regular eating, and a realistic expectation that the first weeks of dose changes can feel off. This guide shows the simplest levers that reliably help
Most people experience some side effects, particularly during dose escalations
Patients generally require very little, if any, post-operative pain medication
Those who fall short of this threshold typically remain late responders throughout treatment, achieving lower total weight loss despite continuing the protocol
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