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After entering the cochlea, cisplatin is taken up into cells by diffusive and passive transport, copper transporter protein 1 (Ctr1) and organic cation transporter protein 2 (OCT2), endocytosis, and toxicity through DNA adduct formation, oxidative stress, mitochondrial dysfunction, inflammatory response, and ferroptosis ( 2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Mukherjea et al., 2011)
No pattern of serious adverse events has been observed in the human studies completed to date
Does glutathione remove tan and pigmentation
Known for its powerful antioxidant properties and skin lightening benefits, glutathione has become a game changer in the cosmetic industry
If youre not drinking enough water, your skin can become dry and flaky, which can make any pigmentation or blemishes more noticeable
It protects cells from free radical damage and plays a role in drug metabolism, protein synthesis, and immune The Benefits of Glutathione Injections What is Glutathione Injection
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