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Biochemistry of the pentose phosphate pathway (PPP) Glucose-6-phoshphate dehydrogenase (G6PD) is the enzyme for the first step of the pentose phosphate pathway (also called hexose monophosphate shunt or phosphogluconate pathway ) G6PD reduces NADP to NADPH while oxidizing glucose-6-phosphate, which is the rate-limiting step of the pathway The pentose phosphate pathwayis a metabolic pathway which uses glucose-6-phosphate to produce: NADPH (most important) Phosphorylated sugars F6P and GAP
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This vital recycling process is driven by an enzyme called glutathione reductase, which utilizes NADPH (a derivative of vitamin B3) to break the disulfide bond and regenerate two fresh, active GSH molecules
Another study from 2022 found it to downregulate UV-B induced inflammation
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[55] have suggested that the relative stability of methionine is due to the complicated kinetics of MAT-I and MAT-III and we have confirmed this by model experiments [56]
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