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Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB2) tool for RCTs, the Newcastle-Ottawa Scale (NOS) for cohort studies, and Joanna Briggs Institute (JBI) checklists for case reports, case series, and pharmacovigilance studies
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While this treatment can be used on many areas of the body, it is commonly applied to the face, neck, chest, abdomen, thighs, knees, elbows, and upper arms
Within a substrate-aware framework, clinical surveillance may therefore include periodic assessment of (i) lean mass trajectory, (ii) micronutrient statusparticularly nutrients supporting enzymatic throughput and redox cyclingand (iii) fat-soluble vitamin indices as indirect indicators of bile-dependent absorption integrity
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