If you have significant diabetes or weight-related health issues, the benefits to your health might outweigh the small theoretical risks
Redox Biol 11:403414 Clausen J, Nielsen SA (1988) Comparison of whole-blood selenium values and erythrocyte glutathione-peroxidase activities of normal individuals on supplementation with selenate, selenite, L-selenomethionine, and high selenium yeast
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The variant was also linked to a higher risk of gastrointestinal side effects, which can themselves suppress appetite and contribute to weight loss
Studies in obese mice reported changes in fat mass and metabolic markers after NNMT inhibition
Searing DA, Zhang Y, et al