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Rinaman explained that when GLP-1R agonist drugs are given systemically, they are not recruiting the central GLP-1 endogenous neurons but are accessing a subset of the receptors
This potentially offers superior outcomes in weight reduction and glycemic control
Because of the roughly six day half life, the drug accumulates to a steady level over several weeks at any given dose
Following treatment discontinuation (after 2 years, or earlier due to non-response or adverse events), treatment effects were assumed to decline according to a catch-up rate until BMI returned to baseline
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