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10.1186/1471-2148-8-39 BMC Evol
Repeated activation of the receptors can lead to upregulation and sensitization, causing hyperexcitability of the receptor even at low levels
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The related Lilly drug tirzepatide lists hair loss as a common side effect on its approved label, and alopecia has also been reported in trials of the newer oral drug orforglipron, which is consistent with a class effect driven by weight loss rather than by one specific molecule
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