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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]
Jung et al., 2013)
However, more long-term, controlled studies are needed to establish the safety of the proposed therapy
J Accad Nutr Diet
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