Particularly, it determined the upregulation of ROS-scavenging enzymes, anti-inflammatory cytokines, (IL-10, IL-6 and PPAR ), tight junctions proteins, such as ZO-1, MUC-2, claudin-3, and the downregulation of inflammatory genes (TNF-, IL-1) [14]
Oxidative stress in human health and disease
4.3% of adults taking semaglutide vs 0.7% on placebo quit the trial because of gastrointestinal issues
Common gastrointestinal side effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain, which may overlap with Crohn's symptoms
For instance, some patients may feel conflicted about their changing relationship with food, experience body image shifts, or deal with external pressure around their weight loss success
And also keep in mind that GLP-1s may cause temporary blurry vision due to fluid shifts we see as glucose levels decrease