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These phosphorylated R-SMADs dissociate from the receptor and form a trimeric complex with SMAD4, which translocates into the nucleus to regulate transcription of fibrosis-related genes, including -smooth muscle actin (-SMA) and collagen I [40, 41]

5, with treatment as schematized in Fig

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A variety of inflammatory mediators and cell adhesion molecules are involved in the regulation of inflammation, and the interactions between them together constitute a complex regulatory network (Gao et al., 2019a)

Effect of superoxide dismutase on the stability of S-nitrosothiols

Second, some research suggests that glutathione may influence melanin synthesis pathways through its interaction with tyrosinase, the enzyme that catalyzes melanin production