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Both substances can stress the liver, and together they increase the risk of liver damage

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Moreover, neuron-derived glial cell line-derived neurotrophic factor (GDNF) upregulates VE-cadherin and claudin-5 expression in brain endothelial cells via PI3K/AKT/Ets-1 and MAPK/ERK/Ets-1 signaling pathways, as demonstrated in brain-specific GDNF-silencing mouse models [237]

10.1016/j.cell.2011.08.039 Cell 103 ProuseM

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