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New England Journal of Medicine , 387(3), 205-216

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-arrestin-biased proteinase-activated receptor-2 antagonist C781 limits allergen-induced airway hyperresponsiveness and inflammation

These studies use MT-1 as the pharmacological probe for characterising the functional consequences of MC1R genetic variation

A plot of the concentration versus the time was then generated in able to find the degradation kinetic constant and calculate the half life Microsomal metabolism was also examined by the research team using the liver microsomes from male rats and an NADPH-regenerating system prepared by adding 1.7 mg/ml NADP, 7.8 mg/ml glucose 6-phosphate, and 6 U/ml glucose-6-phosphate dehydrogenase to 10 ml of 2% sodium bicarbonate