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Both trials enrolled predominantly high-risk populations81% of LEADER and 83% of SUSTAIN-6 participants had established cardiovascular disease [3]
Result: LDL (bad cholesterol) Triglycerides HDL (good cholesterol) 3) Indications Hyperlipidemia Prevention of heart attack & stroke Coronary artery disease (CAD) Diabetes with high cholesterol 4) Common Doses 10 mg 20 mg 40 mg 80 mg (Usually once daily, at night preferred) 5) Important Side Effects Common: Muscle pain (myalgia) Headache Nausea Serious: Rhabdomyolysis (rare but dangerous) Liver toxicity ( LFTs) 6) Key Drug Interactions Avoid with: Macrolide antibiotics (e.g., Clarithromycin) Azole antifungals Grapefruit juice Risk: Increased statin toxicity 7) Monitoring Parameters Lipid profile Liver function tests (LFTs) CK level (if muscle pain) 8) Clinical Pearl Statins are first-line drugs for cardiovascular risk reduction
Some weeks might bring noticeable changes on the scale, while others may reveal progress in how your clothes fit, improved energy levels, or better blood pressure readings
Semaglutide is a groundbreaking medication
Low levels can lead to fatigue, weight gain, decreased strength, and brain fog
Novo Nordisk) oral tablets are now available in sufficient quantities to support initiation of GLP-1 RA treatment in type 2 diabetes mellitus (T2DM) and can be prescribed in line with National Institute for Health and Care Excellence (NICE) guidance
