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In one of the first studies to provide exogenous GLP-1 to humans it was found plasma insulin levels rose significantly and glucose and glucagon concentrations fell (Kreymann et al., 1987)
Nizam AAK, Fadilah NIM, Ahmad H, Maarof M, Fauzi MB
The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling
Most symptoms improve within 4-8 weeks as the body adjusts to therapy
Can I use sterile water instead
Human pharmacokinetics, doseresponse, and mechanism validation remain limited
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