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Wild-type IDH1 overexpression fully rescued the phenotype, demonstrating that the observations are not due to off-target effects (Extended Data Fig

GLP-1 receptor agonists such as semaglutide work by stimulating the pancreas to release insulin when blood sugar levels rise, while also reducing the levels of glucagon, a hormone that increases blood sugar

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Proper monitoring prevents problems

Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis

CELLg8 has developed a liposomal delivery technology that creates very small and stable liposomes, improving the absorption of the liposomes and their contents