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Monitor your blood glucose closely and talk to your provider about adjusting other medications if needed
A total of 577 patients were randomly assigned (1:1:1) to receive once-weekly dulaglutide (1.5 mg), once-weekly dulaglutide (0.75 mg), or daily insulin glargine as basal therapy, all in combination with insulin lispro, for 52 weeks
In STEP-1 (N=1,961), semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks versus 2.4% with placebo, and the lipid improvements tracked closely with this weight reduction 1
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Key findings show that while 33% of semaglutide-induced weight loss was from lean mass loss, the combination therapy achieved better body composition outcomes
Topiramate, originally approved for seizure management and migraine prevention, reduces appetite by modulating GABA receptors and carbonic anhydrase activity
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