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In adults without type 2 diabetes, orforglipron 36mg demonstrated a comparable cardiometabolic profile to oral semaglutide 25mg (CEI 0.67 vs

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Visible waistline and body composition changes emerge in weeks three to six as the cumulative lipolytic effect on visceral fat accumulates

for example, about 20.9% average body-weight loss at the 15 mg dose over 72 weeks in SURMOUNT-1

For instance, Beiu et al

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