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The results of the subgroup analysis in this study were similar
Giordano, A
A pilot randomized controlled clinical trials
Doubling daily KLOW intake (5 mg instead of 2.5 mg) produces stronger receptor downregulation without proportional metabolic benefit and may trigger transient side effects elevated heart rate, jitteriness, or sleep disruption if the double dose occurred in the evening
Depending on treatment response and tolerability of side effects, 7 or 14 mg is used as a long-term maintenance dose
it remains to be seen how it will fare in the current Congress
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