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Against this backdrop of rising obesity and new pharmacologic strategies, it is critical to note that the majority of patients undergoing orthopedic surgery, particularly joint arthroplasty, meet criteria for obesity (BMI 3039.9) or morbid obesity (BMI 40)

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7 Clinical failures and translational limitations of PDE1B and PDE10A inhibitors in schizophrenia Given compelling preclinical data supporting PDE1B and PDE10A inhibition as therapeutic strategies for schizophrenia, the translation of these findings into clinical success has been significantly limited (Table 2)

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