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Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

Consumer Guidance: Is It Worth Considering

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Exceptions: If youve been off the medication for more than 2 weeks, restart at a lower dose to re-acclimate to GI effects If youre switching from semaglutide to tirzepatide (or vice versa) at the same time as brand-to-compounded, restart at the lowest dose of the new drug If the compounded formula includes a non-standard combination (B12, glycine), the clinician may adjust based on tolerance If youve been off for under 2 weeks, continuing at the same dose is usually fine

Filler-dissolving injections do not cause significant pain because the doctor uses a local anesthetic to reduce discomfort

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