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Even with sophisticated delivery systems, achieving oral bioavailability above 1-2% for a peptide drug was long considered an exceptional achievement

This classification was based on the premise that oxidative stress reflects an imbalance between increased oxidative damage and reduced antioxidant capacity

Authors contributions TAS, DK, JS conducted the literature search and selected articles for review

Wang Y, Sharma RK, Falcone T, Goldberg J, Agarwal A

doi: 10.1007/s00403-024-02895-4

Effect of local administration of insulin-like growth factor I combined with inside-out artery graft on peripheral nerve regeneration