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Cyanocobalamin is the most widely available synthetic form, is shelf-stable, and is FDA-approved for treating B12 deficiency
In one study, by artificially creating pain responses in mice, it was observed that vitamin B12 and non-steroidal anti-inflammatory drugs had the same effect of inhibiting cyclooxygenase, thereby concluding the fact that they had a pain-relieving effect (35)
No dose adjustment is required for elderly patients based on age alone
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