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Triple activation (retatrutide) pushes weight loss even further while adding unique benefits for liver health and energy expenditure, but with less long-term safety data and some novel side effects

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doi: 10.1016/j.molmet.2021.101181 109 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al

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Key research findings include: Average 24.2% body weight reduction in Phase 2 at the highest dose cohort over 48 weeks Significant reductions in waist circumference, triglycerides, and fasting glucose Weekly subcutaneous injection (half-life approximately 6 days) Most common adverse events: nausea, vomiting, diarrhea (typical of GLP-1 class) Requires cold chain storage (28C refrigerated)

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