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Yet, alterations in EEC numbers and secretion of gut hormones have also been observed in intestinal inflammation and were implicated in the changes in feeding patterns often accompanying these conditions (146, 147) (Figure 4)

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To more rigorously test this recovery under severe pathological conditions, we utilized a previously established severe reactive astrocyte model, fGiD, 12 which induces more pronounced neurodegeneration, and KDS12025 remarkably reversed cognitive and neuronal deficits

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