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The observed reduction in AUD risk is particularly noteworthy given the global burden of AUD, which affects an estimated 280 million people and is associated with high morbidity and mortality [34]

Metabolic reprogramming of fatty acid and gut microbiotas alteration may form positive feedback in CRC The gut microbiota serves as a bridge between fatty acids and the host, influencing host fatty acid metabolism through a microbe-host co-metabolism network [169, 170], which in turn affects fatty acid digestion and absorption

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Available since 2012, it is FDA-approved for individuals with a body mass index (BMI) of 30 or more, or 27 with an accompanying condition such as hypertension or diabetes

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