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Mol Pharmacol (2000) 57:44652.10.1124/mol.57.3.446 79 LinRKarpaKKabbaniNGoldman-RakicPLevensonR

2.5.3 Melanocortin-1 receptor agonist 2.5.3.1 PL-8177 Melanocortin-1 receptor agonists exert anti-inflammatory and tissue-protective effects in the intestinal mucosa, with PL-8177 demonstrating promising clinical signals in early Phase trials

31.4% at the 12 mg dose over 36 weeks, alongside the 23-26% reductions in total fat mass at the higher doses

Nabavi SM, et al

The test method must be suitable for its intended purpose

However, it appears that GLP-1 drugs may have other beneficial effects on joints, such as anti-inflammatory and pain-relieving properties