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Here, we conduct an umbrella review including 123 meta-analyses covering 464 outcomes from 5617 articles to comprehensively assess the effectiveness and adverse events (AEs) of GLP-1 RAs across diverse outcomes

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The presence of multiple GSTs with overlapping functions and substrate specificities might preclude the observation of phenotypic alteration in knockout mutants (Sappl et al., 2009)

Glutathione S-transferases (GSTs) are the enzymes expressed in the cytosol, microsomes, and mitochondria and catalyze glutathione conjugation to electrophilic compounds, not only produced from exogenous xenobiotics by biotransformation but also arise from endogenous substances

tb observed with INH treatment, compared to the control group at both 8 days ( Figure 3F ) and 15 days post-infection ( Figure 3G )

The count matrix was normalised with the blinded variance-stabilising method from DESeq2 with subsequent differential gene expression analysis 74