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Through the NOX4-ROS pathway, MYC increases nucleotide oxidation, while NUDT1 depletion exacerbates this process, resulting in cell death

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Pulsatile GH signals also activate organ-specic second messenger signaling pathways, such as the Signal Transducer and Activator of Transcription 5B (stat5B) in the liver, with subsequent induction of specic genomic responses in relevant target tissues