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Instead, the selected literature was analyzed and synthesized thematically, with studies grouped according to biological pathways (e.g., monoaminergic modulation, neurotrophic signaling, HPA-axis regulation, neuroinflammation, oxidative stress, and mitochondrial function) and level of evidence (preclinical versus clinical)
Gulewitch VS, Krimberg R
For example, high-dose intravenous (IV) injections deliver a concentrated amount of the antioxidant directly into the bloodstream
The further analysis showed that G/D-CuP could significantly enhance the transition of macrophage phenotypes from M1 to M2 (Fig
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