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Description

Ann Intern Med 169:741750 Website ICER, Accessed June 17, 2025

Its primary mode of action is as a mu-opioid receptor agonist, meaning it binds to the same kind of receptors that morphine acts upon in the brain and spinal cord

Individuals with sensitive skin may benefit from patch testing before regular use

Consistent adherence to the full schedule produces the best long-term outcomes.

Monitor urine color and frequency

is a consultant to Cirius Therapeutics Inc, CSL Behring, Fortress Biotech, Mellitus Health, Neurimmune AG, Pendulum Therapeutics, Stability Health and Zealand Pharma