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Understanding semaglutide withdrawal symptoms and how to maintain weight loss after stopping GLP-1 medications both emphasize the importance of having a dietary strategy in place before discontinuation

Pre-clinical data from studies that combine GLP-1R agonism with other weight loss strategies such as AGB or other metabolic hormones have highlighted more potent options for weight loss

The most frequently reported issues include: Nausea : 21.49% of patients Diarrhea : 10.62% Vomiting : 9.10% Dyspepsia (indigestion) : 8.67% Constipation : 7.92% Decreased appetite : 5.49% While many tolerate these medications well, over 10% of patients stop or interrupt treatment due to severe discomfort

Journal of Endocrinology , 157(2), 205213

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