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The pivotal SURPASS clinical trial programme, which evaluated the efficacy and safety of tirzepatide in thousands of patients with type 2 diabetes, did not identify RLS or restless leg symptoms as a recognised adverse effect
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Based on the American Association of Poison Control Centers National Poison Data System, ~ 7,750 exposures to VPA including 119 severe and 2 fatal cases were reported in 2019 [2]
The incidence of severe hypoglycemia in pediatric patients with type 1 diabetes receiving TOUJEO as part of a multiple daily injection regimen was 6% at 26 weeks and the incidence of hypoglycemia accompanied by a self-monitored or plasma glucose value less than 54 mg/dL regardless of symptoms was 80.3%
Cones Cones are concentrated in the fovea centralis, the most sensitive region of the retina
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