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It suppresses the IL-6/STAT3 pathway, thereby preventing the HCC cells from inhibiting the cytotoxic effect mediated by natural killer cells (NKs) ( + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7

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Dapagliflozin treatment ameliorates HG-induced oxidative stress and apoptosis, as manifested by decreased ROS levels, fewer apoptotic nuclei, and downregulated Nox4 and TGF- expression (124)

When glucose circulates in the blood, it can attach to hemoglobin, forming glycated hemoglobin, or hemoglobin A1c (HbA1c)

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