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Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood
The initial search identified 317 studies, all of which were reviewed
Mechanism is not fully characterized
Until interaction data become available, prescribers should monitor hemodynamic parameters (blood pressure, heart rate) more closely when these agents are combined
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Vigorous shaking creates mechanical stress that breaks these bonds, rendering the peptide inactive
